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KMID : 0380020170320040319
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Korean Journal of Biotechnology and Bioengineering
2017 Volume.32 No. 4 p.319 ~ p.327
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Inhibitory Activity of Sargassum hemiphyllum Ethanol Extract on Inflammatory Response in LPS-induced RAW 264.7 Cells and Mouse Model
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Kim Min-Ji
Kim Koth-Bong-Woo-Ri
Park Sun-Hee
CHoi Jung-Su
Ahn Dong-Hyun
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Abstract
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The anti-inflammatory activity of Sargassum hemiphyllum ethanol extract (SHEE) was investigated using RAW 264.7 cells and ICR mice in this study. As a result, SHEE inhibited the secretion of cytokines including interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α in RAW 264.7 cells without any cytotoxicity. Furthermore, it reduced not only the production of nitric oxide (NO) but also the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, nuclear factor (NF)-kappa B, and mitogenactivated protein kinases (MAPKs) in a dose-dependent manner. The formation of mouse ear edema and the number of infiltrated mast cells under croton oil-induced mouse model were inhibited after treatment of SHEE. These results suggest that SHEE can be used for treating inflammatory diseases as a natural anti-inflammatory resource in modern industry.
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KEYWORD
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Sargassum hemiphyllum, anti-inflammation, nuclear factor-kappa B, mitogen-activated protein kinases
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